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The penis is composed of two columns of erectile tissue (the corpora
cavernosa); the corpus spongiosum, which contains the tube that carries urine
and semen from the body (urethra); and the sheath that surrounds the erectile
tissue (tunica albuginea). In Peyronie’s disease, dense, fibrous scar tissue
(plaque) forms in the tunica albuginea.
Penis anatomy with pictures >>>
According to medical reports, the Peyronie’s disease is most common between
the ages of 45 and 60, but it also occurs in young and elderly men.
Causes
The cause of this disease is unknown. Cases that develop suddenly are often
caused by trauma to the penis for example invasive penile procedure, injury,
extremely vigorous sexual activity.
Peyronie's disease may be mild or severe, and may develop rapidly or over time. Symptoms include the following:
- Hardened tissue (plaque) in the penis
- Pain during erection
- Curve in the penis during erection
- Distortion of the penis (e.g., indentation, shortening)
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Cases of Peyronie's that develop over time may be caused by an inherited
abnormality of human leukocyte antigen B27 (HLA-B27), suggesting a genetic link.
Also, Peyronie's occurs more frequently in men with family members who have the
condition or a connective tissue disorder (e.g., systemic lupus erythematosus).
About 30% of patients with Peyronie’s disease also develop hardened tissue in
other parts of the body, such as the hand (e.g., Dupuytren’s contracture) or the
foot.
Signs and Symptoms
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Plaque usually develops on the top of the shaft, causing the penis to bend
upward during erection, but it may occur on the bottom, causing a downward bend.
If plaque develops on the top and the bottom, indentations and shortening may
occur. In about 13% of cases, plaque does not cause severe pain or curvature,
and the condition resolves on its own.
In severe cases, pain and curvature result in erectile dysfunction impotence.
If there are several areas of plaque, incomplete erection may occur.
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